Welcome to the Softic Lab
The Softic Lab studies how dietary sugar (fructose and glucose) metabolism affects energy homeostasis in the liver.
The long-term goal of our research is to define how the combined intake of sugar and a high-fat diet (HFD) promotes the development of non-alcoholic fatty liver disease (NAFLD) and insulin resistance. The current work of the Softic Lab spans across four major areas of interests. These include:
- The effects of fructose on cellular energy homeostasis in the liver.
- Uncovering pathways by which fructose induces hepatic insulin resistance.
- Delineating regulators of fructose metabolism (ketohexokinase) in the liver and other tissue.
- Clinical studies to assess the effects of dietary sugar on the development of NAFLD in children.
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