Welcome to the Softic Lab

The Softic Lab studies how dietary sugar (fructose and glucose) metabolism affects energy homeostasis in the liver.

The long-term goal of our research is to define how the combined intake of sugar and a high-fat diet (HFD) promotes the development of non-alcoholic fatty liver disease (NAFLD) and insulin resistance. The current work of the Softic Lab spans across four major areas of interests. These include:

1. The effects of fructose on cellular energy homeostasis in the liver.
2. Uncovering pathways by which fructose induces hepatic insulin resistance.
3. Delineating regulators of fructose metabolism (ketohexokinase) in the liver and other tissue.
4. Clinical studies to assess the effects of dietary sugar on the development of NAFLD in children.

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