Publications

Selected publications:

  • Softic S, Meyer JG, Wang GX, Gupta MK, Batista TM, Lauritzen HPMM, Fujisaka S, Serra D, Herrero L, Willoughby J, Fitzgerald K, Ilkayeva O, Newgard CB, Gibson BW, Schilling B, Cohen DE, Kahn CR. Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins. Cell Metab. 2019 Oct 1;30(4):735-753.e4. doi: 10.1016/j.cmet.2019.09.003. PMID: 31577934
    • 30 Google Scholar citations in the first year

Google Scholar

Research Gate

LinkedIn

  • Softic S, Gupta MK, Wang GX, Fujisaka S, O’Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR. Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. J Clin Invest. 2017 Nov 1;127(11):4059-4074. doi: 10.1172/JCI94585. Epub 2017 Oct 3. PMID: 28972537
    • 120 Google Scholar citations in the first three years
  • Softic S, Cohen DE, Kahn CR. Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease. Dig Dis Sci. 2016 May;61(5):1282-93. doi: 10.1007/s10620-016-4054-0. Epub 2016 Feb 8. PMID: 26856717 Review.
    • 257 Google Scholar citations in the first five years

 

Publications in reverse chronological order:

2020


35)

Author Correction: Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.
Saif M, Kwanten WJ, Carr JA, Chen IX, Posada JM, Srivastava A, Zhang J, Zheng Y, Pinter M, Chatterjee S, Softic S, Kahn CR, van Leyen K, Bruns OT, Jain RK, Bawendi MG. 
Nat Biomed Eng. 2020 Dec;4(12):1222. doi: 10.1038/s41551-020-00664-y.Nat Biomed Eng. 2020. PMID: 33235308
34)

Leptin Receptor Signaling Regulates Protein Synthesis Pathways and Neuronal Differentiation in Pluripotent Stem Cells.

Gupta MK, Vethe H, Softic S, Rao TN, Wagh V, Shirakawa J, Barsnes H, Vaudel M, Takatani T, Kahraman S, Sakaguchi M, Martinez R, Hu J, Bjørlykke Y, Raeder H, Kulkarni RN.

Stem Cell Reports. 2020 Nov 10;15(5):1067-1079. doi: 10.1016/j.stemcr.2020.10.001. Epub 2020 Oct 29. PMID: 33125875

33)

Tissue-Specific Fructose Metabolism in Obesity and Diabetes.

Helsley RN, Moreau F, Gupta MK, Radulescu A, DeBosch B, Softic S.

Curr Diab Rep. 2020 Oct 15;20(11):64. doi: 10.1007/s11892-020-01342-8. PMID: 33057854 Review.

32)

Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance.

Wang G, Yu Y, Cai W, Batista TM, Suk S, Noh HL, Hirshman M, Nigro P, Li ME, Softic S, Goodyear L, Kim JK, Kahn CR.

Diabetes. 2020 Nov;69(11):2294-2309. doi: 10.2337/db20-0439. Epub 2020 Aug 31. PMID: 32868340

31)

Evolving Role for Pharmacotherapy in NAFLD/NASH.

Attia SL, Softic S, Mouzaki M.

Clin Transl Sci. 2020 Jun 25. doi: 10.1111/cts.12839. Online ahead of print. PMID: 32583961

30)

Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.

Saif M, Kwanten WJ, Carr JA, Chen IX, Posada JM, Srivastava A, Zhang J, Zheng Y, Pinter M, Chatterjee S, Softic S, Kahn CR, van Leyen K, Bruns OT, Jain RK, Bawendi MG.

Nat Biomed Eng. 2020 Aug;4(8):801-813. doi: 10.1038/s41551-020-0569-y. Epub 2020 Jun 22. PMID: 32572196

29)

Fructose metabolism by the guts cuts liver fat.

Helsley RN, Softic S.

J Mol Med (Berl). 2020 May;98(5):733-734. doi: 10.1007/s00109-020-01912-z. Epub 2020 Apr 21. PMID: 32318746

28)

Fructose and hepatic insulin resistance.

Softic S, Stanhope KL, Boucher J, Divanovic S, Lanaspa MA, Johnson RJ, Kahn CR.

Crit Rev Clin Lab Sci. 2020 Aug;57(5):308-322. doi: 10.1080/10408363.2019.1711360. Epub 2020 Jan 14. PMID: 31935149

 

2019


27)

Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins.

Softic S, Meyer JG, Wang GX, Gupta MK, Batista TM, Lauritzen HPMM, Fujisaka S, Serra D, Herrero L, Willoughby J, Fitzgerald K, Ilkayeva O, Newgard CB, Gibson BW, Schilling B, Cohen DE, Kahn CR.

Cell Metab. 2019 Oct 1;30(4):735-753.e4. doi: 10.1016/j.cmet.2019.09.003. PMID: 31577934

26)

Hepatocyte Stress Increases Expression of Yes-Associated Protein and Transcriptional Coactivator With PDZ-Binding Motif in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis.

Mooring M, Fowl BH, Lum SZC, Liu Y, Yao K, Softic S, Kirchner R, Bernstein A, Singhi AD, Jay DG, Kahn CR, Camargo FD, Yimlamai D.

Hepatology. 2020 May;71(5):1813-1830. doi: 10.1002/hep.30928. Epub 2020 Jan 3. PMID: 31505040

25)

Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism.

Li ME, Lauritzen HPMM, O’Neill BT, Wang CH, Cai W, Brandao BB, Sakaguchi M, Tao R, Hirshman MF, Softic S, Kahn CR.

Nat Commun. 2019 Jul 30;10(1):3412. doi: 10.1038/s41467-019-11265-y. PMID: 31363081

24)

Risk-factors Associated With Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review.

Lekbua A, Ouahed J, O’Connell AE, Kahn SA, Goldsmith JD, Imamura T, Duncan CN, Kelsen JR, Worthey E, Snapper SB, Softic S.

J Pediatr Gastroenterol Nutr. 2019 Jul;69(1):e13-e18. doi: 10.1097/MPG.0000000000002297. PMID: 31232887

23)

Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.

Wang G, Meyer JG, Cai W, Softic S, Li ME, Verdin E, Newgard C, Schilling B, Kahn CR.

Mol Cell. 2019 May 16;74(4):844-857.e7. doi: 10.1016/j.molcel.2019.03.021. Epub 2019 Apr 15. PMID: 31000437

 

2018


22)

Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose.

Meyer JG, Softic S, Basisty N, Rardin MJ, Verdin E, Gibson BW, Ilkayeva O, Newgard CB, Kahn CR, Schilling B.

PLoS One. 2018 Dec 26;13(12):e0208973. doi: 10.1371/journal.pone.0208973. eCollection 2018. PMID: 30586434

21)

Fatty liver disease: is it nonalcoholic fatty liver disease or obesity-associated fatty liver disease?

Softic S, Kahn CR.

Eur J Gastroenterol Hepatol. 2019 Jan;31(1):143. doi: 10.1097/MEG.0000000000001279. PMID: 30507644

20)

Attenuation of PKCδ enhances metabolic activity and promotes expansion of blood progenitors.

Rao TN, Gupta MK, Softic S, Wang LD, Jang YC, Thomou T, Bezy O, Kulkarni RN, Kahn CR, Wagers AJ.

EMBO J. 2018 Dec 14;37(24):e100409. doi: 10.15252/embj.2018100409. Epub 2018 Nov 16. PMID: 30446598

19)

Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids.

Garcia-Castillo MD, Chinnapen DJ, Te Welscher YM, Gonzalez RJ, Softic S, Pacheco M, Mrsny RJ, Kahn CR, von Andrian UH, Lau J, Pentelute BL, Lencer WI.

Elife. 2018 May 31;7:e34469. doi: 10.7554/eLife.34469. PMID: 29851380

18)

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.

Softic S, Gupta MK, Wang GX, Fujisaka S, O’Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR.

J Clin Invest. 2018 Mar 1;128(3):1199. doi: 10.1172/JCI99009. Epub 2018 Mar 1. PMID: 29493547

 

2017


17)

Hepatic Natural Killer T-cell and CD8+ T-cell Signatures in Mice with Nonalcoholic Steatohepatitis.

Bhattacharjee J, Kirby M, Softic S, Miles L, Salazar-Gonzalez RM, Shivakumar P, Kohli R.

Hepatol Commun. 2017 Jun;1(4):299-310. doi: 10.1002/hep4.1041. Epub 2017 May 16. PMID: 29152605

16)

Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR, Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S.

Nat Med. 2017 Oct 6;23(10):1241. doi: 10.1038/nm1017-1241c. PMID: 28985207

15)

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.

Softic S, Gupta MK, Wang GX, Fujisaka S, O’Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR.

J Clin Invest. 2017 Nov 1;127(11):4059-4074. doi: 10.1172/JCI94585. Epub 2017 Oct 3. PMID: 28972537

14)

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR, Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S.

Nat Med. 2017 Jul;23(7):829-838. doi: 10.1038/nm.4346. Epub 2017 Jun 12. PMID: 28604704

 

2016


13)

Antibiotic effects on gut microbiota and metabolism are host dependent.

Fujisaka S, Ussar S, Clish C, Devkota S, Dreyfuss JM, Sakaguchi M, Soto M, Konishi M, Softic S, Altindis E, Li N, Gerber G, Bry L, Kahn CR.

J Clin Invest. 2016 Dec 1;126(12):4430-4443. doi: 10.1172/JCI86674. Epub 2016 Oct 24. PMID: 27775551

12)

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis.

O’Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, Nair KS, Kahn CR.

J Clin Invest. 2016 Sep 1;126(9):3433-46. doi: 10.1172/JCI86522. Epub 2016 Aug 15. PMID: 27525440

11)

Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function.

Boucher J, Softic S, El Ouaamari A, Krumpoch MT, Kleinridders A, Kulkarni RN, O’Neill BT, Kahn CR.

Diabetes. 2016 Aug;65(8):2201-13. doi: 10.2337/db16-0212. Epub 2016 May 13. PMID: 27207537

10)

Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD.

Softic S, Boucher J, Solheim MH, Fujisaka S, Haering MF, Homan EP, Winnay J, Perez-Atayde AR, Kahn CR.

Diabetes. 2016 Aug;65(8):2187-200. doi: 10.2337/db16-0213. Epub 2016 May 10. PMID: 27207510

9)

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease.

Softic S, Cohen DE, Kahn CR.

Dig Dis Sci. 2016 May;61(5):1282-93. doi: 10.1007/s10620-016-4054-0. Epub 2016 Feb 8. PMID: 26856717 Review.

 

Before 2015


8)

Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome.

Ussar S, Griffin NW, Bezy O, Fujisaka S, Vienberg S, Softic S, Deng L, Bry L, Gordon JI, Kahn CR.

Cell Metab. 2015 Sep 1;22(3):516-530. doi: 10.1016/j.cmet.2015.07.007. Epub 2015 Aug 20. PMID: 26299453

7)

IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice.

Harley IT, Stankiewicz TE, Giles DA, Softic S, Flick LM, Cappelletti M, Sheridan R, Xanthakos SA, Steinbrecher KA, Sartor RB, Kohli R, Karp CL, Divanovic S.

Hepatology. 2014 May;59(5):1830-9. doi: 10.1002/hep.26746. Epub 2014 Mar 27. PMID: 24115079

6)

Subcutaneous Adipose Tissue Transplantation in Diet-Induced Obese Mice Attenuates Metabolic Dysregulation While Removal Exacerbates It.

Foster MT, Softic S, Caldwell J, Kohli R, de Kloet AD, Seeley RJ.

Physiol Rep. 2013 Aug;1(2):e00015. doi: 10.1002/phy2.15. PMID: 23914298

5)

Insulin concentration modulates hepatic lipid accumulation in mice in part via transcriptional regulation of fatty acid transport proteins.

Softic S, Kirby M, Berger NG, Shroyer NF, Woods SC, Kohli R.

PLoS One. 2012;7(6):e38952. doi: 10.1371/journal.pone.0038952. Epub 2012 Jun 20. PMID: 22745692

4)

Transplantation of non-visceral fat to the visceral cavity improves glucose tolerance in mice: investigation of hepatic lipids and insulin sensitivity.

Foster MT, Shi H, Softic S, Kohli R, Seeley RJ, Woods SC.

Diabetologia. 2011 Nov;54(11):2890-9. doi: 10.1007/s00125-011-2259-5. Epub 2011 Jul 30. PMID: 21805228

3)

High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis.

Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ.

Hepatology. 2010 Sep;52(3):934-44. doi: 10.1002/hep.23797. PMID: 20607689

2)

Nonhealing diaper rash with associated hepatosplenomegaly

 French JA, Softich S.

Am Fam Physician. 2009 Dec 15;80(12):1481. PMID: 20000311

1)

Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway.

Karp CL, Flick LM, Park KW, Softic S, Greer TM, Keledjian R, Yang R, Uddin J, Guggino WB, Atabani SF, Belkaid Y, Xu Y, Whitsett JA, Accurso FJ, Wills-Karp M, Petasis NA.

Nat Immunol. 2004 Apr;5(4):388-92. doi: 10.1038/ni1056. Epub 2004 Mar 21. PMID: 15034576